Persistent polyclonal B lymphocytosis with multiple bcl-2/IgH rearrangements: a benign disorder.

نویسندگان

  • E Granados
  • P Llamas
  • I Pinilla
  • J F Tomás
  • P Font
  • R Cámara
  • F Olmeda
  • R Arranz
  • J M Fernández-Rañada
چکیده

The appearance of a chronic B lymphocytosis is usually associated with the existence of an underlying monoclonal malignant condition. However, a few cases of persistent polyclonal B cell lymphocytosis (PPBL), presented in young asymptomatic women with an uneventful course, have been reported in recent years. In these PPBL cases, since the lymphocytes usually display an anomalous morphology, a false diagnosis of a neoplastic chronic lymphoproliferative syndrome can be easily made. We report a typical case of PPBL that presents multiple bcl-2 rearrangements, the typical finding of follicular lymphomas. A review of different causes of benign non neoplastic lymphocytosis with special steadiness in changes in the lymphoid subsets will be made.

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عنوان ژورنال:
  • Haematologica

دوره 83 4  شماره 

صفحات  -

تاریخ انتشار 1998